La seguente tesi si propone di sviluppare a livello esecutivo alcuni degli interventi strutturali necessari
alla completa ristrutturazione del complesso del Museo Ebraico e Sinagoghe sito nel Ghetto di
Venezia.
La progettazione si basa sul progetto esecutivo architettonico in essere, sul quale sono state svolte
considerazioni architettoniche e strutturali di concerto con i progettisti che hanno realizzato il
progetto definitivo strutturale e che sono incaricati di svilupparne l’esecutivo...
È stato condotto uno studio osservazionale retrospettivo raccogliendo i dati clinici e bioumorali di 39 pazienti consecutivi sottoposti a procedure cardiologiche invasive ad elevato rischio di contrast-induced acute kidney injury (CI-AKI) per la presenza di malattia renale cronica (chronic kidney disease, CKD) dallo stadio G3 allo stadio G5 e almeno un altro fattore di rischio associato (diabete mellito, ipertensione arteriosa, vasculopatia, scompenso cardiaco, precedente somministrazione di ...
Introduzione. In letteratura sono stati sviluppati diversi sistemi di sorveglianza sindromica. Tipicamente le patologie più monitorate sono state quelle respiratorie e gastrointestinali, ma diversi sistemi sono stati implementati in preparazione di eventi di massa per valutare molte sindromi collegate con il bioterrorismo. I sistemi si sono tradizionalmente concentrati sui sintomi e/o le diagnosi raccolte nei setting di Pronto Soccorso o visite ambulatoriali. I metodi statistici più usati son...
Early disease detection and estimation of the sensitivity surveillance system are used for various purposes, including the early detection of non‐communicable diseases, of unusual increases of disease frequency, the first occurrence of a disease in a previously free population, or providing evidence of disease eradication. Quantifying the sensitivity of early detection surveillance allows important aspects of the performance of different systems, approaches and authorities to be evaluated, co...
The mammalian Target of Rapamycin (mTOR) kinase is a master regulator of cell metabolism. Genetic diseases in which mTOR activity is upregulated, such as Tuberous Sclerosis Complex (TSC), are classified as mTORopathies, and are characterized by severe neurological symptoms, including pharmacoresistant epilepsy. However, the mTORC1 downstream effectors responsible for seizure development remain unknown. Preliminary data identified the background K+ channel TREK-1 to be phosphorylated on Ser333...
Schizophrenia is a chronic highly heritable mental health disorder affecting ~1% of the population. Symptoms of schizophrenia usually appear in early adulthood, and it is referred to as adult-onset schizophrenia (AOS). However, very rare and severe form of this disease occurs before the age of 13 and it is known as childhood-onset schizophrenia (COS). Recent studies demonstrated a higher burden of de novo variants in COS patients compared to those with AOS. These findings underscore the need ...
Recent emerging evidence, including our preliminary data, suggests that KMT2D plays a role in the DNA damage response (DDR) and the maintenance of genome integrity (GI). Despite being one of the most frequently mutated genes in cancer, little is known about its biological roles beyond its enhancer-driven function. Therefore, the present study investigates the interplay between the described gene expression function of KMT2D and its emerging role in the DDR. By exploiting siRNA-mediated knockd...
Helicobacter pylori is a prevalent bacterium that colonizes the gastric mucosa of humans. In the 1990s, researchers discovered that H. pylori plays a role in the pathogenesis of gastric diseases. Moreover, Helicobacter pylori produce factors that influence the host on a large scale. Since the discovery of H. pylori, the majority of the research has focused on the pathology of diseases associated with these bacteria and how to eradicate them. However, recent research demonstrates the potential...
The study investigates the impact of the Russo-Ukrainian conflict on Russian students studying abroad, specifically in Italy. Through a comprehensive exploration of the mobility experience before and after the conflict, the research aims to understand how warfare influences international students’ mobility from the point of view of traveling experience, financial constraints, and personal adaptation strategies. The research is conducted with the use of both quantitative (survey) and qualitati...
Exploring the ways in which features of the colonial archive, based on its construction, exclude and include certain voices; particularly those of first nations people in Australia. The period of research is between 1786-1798 as the first fleet of convicts prepare to and invade the continent of Australia for the first time. This exploration delves into characteristics of document acquisition and preservation, revealing the role of public institutions and digital platforms in the collection of...