Testing the potential of the mouse ETiX embryoid model as a screening platform for determining drug toxicity in early developmental stages

From the perspective of translational medicine and developmental toxicology, the central question addressed in this thesis is whether ETiX embryoids can serve as a mechanistically rich, ethically acceptable platform to study drug toxicity during early gestational windows that are inaccessible in humans and incompletely covered by standard in vivo animal studies. The goal is not to replace all animal studies which remain essential for capturing maternal physiology, placental function, and long term outcomes but to provide a complementary system that can dissect early morphogenetic mechanisms, identify sensitive developmental pathways and time windows, help prioritize compounds and doses for further testing, and ultimately contribute to safer pharmacotherapy during pregnancy.