Development of a model-based approach to the characterization and diagnosis of type 1 von Willebrand disease

Von Willebrand disease (VWD) is the most common inherithed bleeding disorder and it is caused by a deficiencies of von Willebrand factor (VWF), which is a glycoprotein fundamental in the coagulation process. Type 1 is the most common VWD variant; through the clinical data and a pharmacokinetic model, an algorithmic approach supporting the diagnosis of type 1 VWD is proposed.