Compartmental Models for the Assessment of Net Whole Body Protein Breakdown Using a Pulse of Phenylalanine and Tyrosine Stable Isotopes in Humans

Two compartmental models of Phe and Tyr metabolism in healthy subjects were developed, by using two stable isotope tracer pulses administered intravenously. The simplest model provides a physiologically relevant overview of Phe and Tyr metabolism in terms of intervals of validity. The more complex one is uniquely identifiable, but makes a higher number of structural assumptions. These models could serve as a future reference in amino acids modeling