The main objective is to study the effects of diet on the circadian clock of human liver cells. High-throughput transcriptomics and proteomics collected from in vitro cell cultures are analysed by means of Bioinformatics and Data Analytics techniques, revealing diet-specific liver functionality. Moreover, an integrated analysis of mRNAs and proteins is performed for determining the role of post-transcriptional and post-translational modifications on the final shaping of circadian rhythms.
Study of the multi-level regulatory mechanisms in the circadian rhythms of human liver cells
Cenci, Francesca
2020/2021
Abstract
The main objective is to study the effects of diet on the circadian clock of human liver cells. High-throughput transcriptomics and proteomics collected from in vitro cell cultures are analysed by means of Bioinformatics and Data Analytics techniques, revealing diet-specific liver functionality. Moreover, an integrated analysis of mRNAs and proteins is performed for determining the role of post-transcriptional and post-translational modifications on the final shaping of circadian rhythms.File in questo prodotto:
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Utilizza questo identificativo per citare o creare un link a questo documento:
https://hdl.handle.net/20.500.12608/28762