The ISOLPHARM collaboration has the aim of producing a set of innovative, high specific activity, carrier-free radionuclides for radiopharmaceutical applications exploiting the ISOL technique at SPES. The success of a particular radiopharmaceutical cancer treatment relies on an accurate assessment of the tissue response and toxicity. Since biological effects are mediated by the absorbed dose, internal dosimetry is of fundamental importance because it allows for the maximization of the therapeutic effect while minimizing the radiation burden to other organs. The thesis work deals with internal absorbed dose Monte Carlo calculations based on Geant4 combined with standard and novel medical images. For some years now, interest has been growing in the use of optical photons emitted by Cerenkov effect for diagnostic purposes. This technique, called Cerenkov luminescence imaging (CLI), could be used in a complementary fashion with PET and SPECT to produce 2D, fast and cost-effective functional images in pre-clinical and clinical settings. An innovative instrument designed for CLI, direct radioisotopic imaging (DRI) and other imaging techniques is the Bruker In-Vivo Xtreme II, available at the CAPiR Laboratory of the University of Catania. Using this instrument, a number of CLI and DRI have been acquired for several radionuclides: Tc-99m, Ga-68. Specific phantoms have been designed and built to define the geometry of the source in a shape that allows the characterization of the spatial resolution, the contrast and other typical features of the instrument. The experimental images will be used to validate the Geant4 simulation framework. The software will be then used to assess the performance of the instrument with the future Ag-111 loaded radiopharmaceutical, with the aim to extract the biodistribution activity and internal dose maps for the future in-vivo experiments at CAPiR expected by the end of this year.

The ISOLPHARM collaboration has the aim of producing a set of innovative, high specific activity, carrier-free radionuclides for radiopharmaceutical applications exploiting the ISOL technique at SPES. The success of a particular radiopharmaceutical cancer treatment relies on an accurate assessment of the tissue response and toxicity. Since biological effects are mediated by the absorbed dose, internal dosimetry is of fundamental importance because it allows for the maximization of the therapeutic effect while minimizing the radiation burden to other organs. The thesis work deals with internal absorbed dose Monte Carlo calculations based on Geant4 combined with standard and novel medical images. For some years now, interest has been growing in the use of optical photons emitted by Cerenkov effect for diagnostic purposes. This technique, called Cerenkov luminescence imaging (CLI), could be used in a complementary fashion with PET and SPECT to produce 2D, fast and cost-effective functional images in pre-clinical and clinical settings. An innovative instrument designed for CLI, direct radioisotopic imaging (DRI) and other imaging techniques is the Bruker In-Vivo Xtreme II, available at the CAPiR Laboratory of the University of Catania. Using this instrument, a number of CLI and DRI have been acquired for several radionuclides: Tc-99m, Ga-68. Specific phantoms have been designed and built to define the geometry of the source in a shape that allows the characterization of the spatial resolution, the contrast and other typical features of the instrument. The experimental images will be used to validate the Geant4 simulation framework. The software will be then used to assess the performance of the instrument with the future Ag-111 loaded radiopharmaceutical, with the aim to extract the biodistribution activity and internal dose maps for the future in-vivo experiments at CAPiR expected by the end of this year.

Monte-Carlo simulations for medical images interpretation in the context of the ISOLPHARM project

SERAFINI, DAVIDE
2021/2022

Abstract

The ISOLPHARM collaboration has the aim of producing a set of innovative, high specific activity, carrier-free radionuclides for radiopharmaceutical applications exploiting the ISOL technique at SPES. The success of a particular radiopharmaceutical cancer treatment relies on an accurate assessment of the tissue response and toxicity. Since biological effects are mediated by the absorbed dose, internal dosimetry is of fundamental importance because it allows for the maximization of the therapeutic effect while minimizing the radiation burden to other organs. The thesis work deals with internal absorbed dose Monte Carlo calculations based on Geant4 combined with standard and novel medical images. For some years now, interest has been growing in the use of optical photons emitted by Cerenkov effect for diagnostic purposes. This technique, called Cerenkov luminescence imaging (CLI), could be used in a complementary fashion with PET and SPECT to produce 2D, fast and cost-effective functional images in pre-clinical and clinical settings. An innovative instrument designed for CLI, direct radioisotopic imaging (DRI) and other imaging techniques is the Bruker In-Vivo Xtreme II, available at the CAPiR Laboratory of the University of Catania. Using this instrument, a number of CLI and DRI have been acquired for several radionuclides: Tc-99m, Ga-68. Specific phantoms have been designed and built to define the geometry of the source in a shape that allows the characterization of the spatial resolution, the contrast and other typical features of the instrument. The experimental images will be used to validate the Geant4 simulation framework. The software will be then used to assess the performance of the instrument with the future Ag-111 loaded radiopharmaceutical, with the aim to extract the biodistribution activity and internal dose maps for the future in-vivo experiments at CAPiR expected by the end of this year.
2021
Monte-Carlo simulations for medical images interpretation in the context of the ISOLPHARM project
The ISOLPHARM collaboration has the aim of producing a set of innovative, high specific activity, carrier-free radionuclides for radiopharmaceutical applications exploiting the ISOL technique at SPES. The success of a particular radiopharmaceutical cancer treatment relies on an accurate assessment of the tissue response and toxicity. Since biological effects are mediated by the absorbed dose, internal dosimetry is of fundamental importance because it allows for the maximization of the therapeutic effect while minimizing the radiation burden to other organs. The thesis work deals with internal absorbed dose Monte Carlo calculations based on Geant4 combined with standard and novel medical images. For some years now, interest has been growing in the use of optical photons emitted by Cerenkov effect for diagnostic purposes. This technique, called Cerenkov luminescence imaging (CLI), could be used in a complementary fashion with PET and SPECT to produce 2D, fast and cost-effective functional images in pre-clinical and clinical settings. An innovative instrument designed for CLI, direct radioisotopic imaging (DRI) and other imaging techniques is the Bruker In-Vivo Xtreme II, available at the CAPiR Laboratory of the University of Catania. Using this instrument, a number of CLI and DRI have been acquired for several radionuclides: Tc-99m, Ga-68. Specific phantoms have been designed and built to define the geometry of the source in a shape that allows the characterization of the spatial resolution, the contrast and other typical features of the instrument. The experimental images will be used to validate the Geant4 simulation framework. The software will be then used to assess the performance of the instrument with the future Ag-111 loaded radiopharmaceutical, with the aim to extract the biodistribution activity and internal dose maps for the future in-vivo experiments at CAPiR expected by the end of this year.
ISOLPHARM
Geant4
Monte-Carlo
Medical imaging
Cerenkov
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12608/37717