Analysis of the blood-to-brain tracer exchange in [18F]DPA714 PET imaging

Positron Emission Tomography (PET) imaging has emerged as a valuable tool for non-invasive investigation of various brain disorders. One area of interest is the analysis of blood-to-brain tracer exchange, which provides insights into the integrity of the blood-brain barrier (BBB) and its potential alterations in neurological conditions. The effects of aging, gender, genotype, body mass index (BMI), and dose over weight (DW) on K1 have been examined in healthy people using a general mixed linear model and step-wise regression. An ANOVA test was then used to examine the K1 values in subjects with and without multiple sclerosis. A reduced compartmental model has been used to extract the value of K1 from 80 healthy controls and 45 patients with multiple sclerosis in the cortex and subcortex areas.