Calcium (Ca2+) plays an important role in neuronal signalling as messenger for signal transduction. Intracellular calcium concentration changes in response to cell excitation and can be recorded with a two photon microscope as a change of fluorescence. The aim of this thesis is to investigate calcium dynamics in human brain organoids, studying single cell and population activities to characterize neuronal network behavior.
Calcium (Ca2+) plays an important role in neuronal signalling as messenger for signal transduction. Intracellular calcium concentration changes in response to cell excitation and can be recorded with a two photon microscope as a change of fluorescence. The aim of this thesis is to investigate calcium dynamics in human brain organoids, studying single cell and population activities to characterize neuronal network behavior.
Development of an imaging approach for investigating calcium dynamics in human brain organoids
MEZZALIRA, FEDERICO
2022/2023
Abstract
Calcium (Ca2+) plays an important role in neuronal signalling as messenger for signal transduction. Intracellular calcium concentration changes in response to cell excitation and can be recorded with a two photon microscope as a change of fluorescence. The aim of this thesis is to investigate calcium dynamics in human brain organoids, studying single cell and population activities to characterize neuronal network behavior.| File | Dimensione | Formato | |
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Mezzalira_Federico.pdf.pdf
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https://hdl.handle.net/20.500.12608/58891