Toward a Substrate Independent Methodology for Chiroptical Sensing of Chiral Amides

The development of fast, cheap, simple and reliable high-throughput screening techniques (HTS) and high-throughput analysis (HTA) approaches is a critical focus in the field of supramolecular and organic chemistry. These experimental means are fundamental for chiral catalysts/auxiliaries discovery in asymmetric synthesis. Furthermore, these approaches are crucial also for the chirality investigation of the reaction outputs, particularly for assessment of absolute configuration and determination of enantiomeric excess. Since the limitations of the traditional analytical techniques, chemists have found promising alternatives in the application of chiroptical spectroscopies and chromophoric supramolecular sensors. This thesis aims to investigate the existence of a multivariate model able to predict the electronic circular dichroism (ECD) readout of a class of different chiral amides, employing an oxo-vanadium(V) aminotriphenolate (TPA) complex previously developed by the research groups where this thesis has been carried out.