The malignant pleural mesothelioma, a neoplasm arising from mesothelioma cells, has a very poor prognosis since the standard chemotherapy has a bad response rate. For this reason, different nanobodies molecules are generated targeting a protein that is overexpressed in cancer cells, the Mesothelin. More in details, this work aim to synthesise and characterise three different nanobodies. For each nanobody, the work can be divided into three phases:cloning, production and purification, characterisation.
Characterisation of anti-Mesothelin nanobodies in order to treat malignant pleural mesothelioma
BUZIOL, LAURA
2022/2023
Abstract
The malignant pleural mesothelioma, a neoplasm arising from mesothelioma cells, has a very poor prognosis since the standard chemotherapy has a bad response rate. For this reason, different nanobodies molecules are generated targeting a protein that is overexpressed in cancer cells, the Mesothelin. More in details, this work aim to synthesise and characterise three different nanobodies. For each nanobody, the work can be divided into three phases:cloning, production and purification, characterisation.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
Buziol_Laura.pdf
accesso riservato
Dimensione
3.5 MB
Formato
Adobe PDF
|
3.5 MB | Adobe PDF |
The text of this website © Università degli studi di Padova. Full Text are published under a non-exclusive license. Metadata are under a CC0 License
Utilizza questo identificativo per citare o creare un link a questo documento:
https://hdl.handle.net/20.500.12608/61185