Extended Ethyl Lauroyl Arginate release: a new drug delivery solution for Oral Care ​

Biofilms are considered the most abundant life state of microorganisms. These structures are sessile and ubiquitous communities of microbes encased in a self-made polymeric matrix. Among several types of biofilms, so-called bad biofilms are considered one of the major challenges and concerns for medicine. Biofilm-related nosocomial infections are generally caused by antimicrobial resistant bacteria, which can escape to antibiotic mode of action with different kinds of mechanisms. Moreover, inside biofilm structures, antimicrobial molecules could become ineffective respect to planktonic counterpart. The primary scope of Brenta’s internal project BAnE (Biofilm Antibiotic Enhancers) is to develop a Trojan horse-like system of particles which can enhance antibiotic activity against biofilms, focusing specifically on orthopaedics' and oral care fields elective molecules.