The ability of cells to respond and adapt to different external mechanical stimuli converting them into biochemical signals falls under the name of mechanotransduction (Discher et al., 2009). Pivotal in such phenomenon are YAP and TAZ, transcriptional co-regulators whose activation is driven by nuclear accumulation triggered by external mechanical inputs (Dupont et al., 2011; Aragona et al., 2013; Piccolo et al., 2014; Zanconato et al., 2016). Despite extensive efforts, the molecular mechanisms regulating YAP/TAZ signaling are still debated. Recently, the mechanical continuum between the cytoskeleton and the nuclear envelope has emerged as fundamental element in YAP/TAZ mechanotransduction (Elosegui-Artola et al., 2017; Janota et al., 2020). Here, we set to investigate how nuclear envelope components and their connection with the cytoskeleton can impact on YAP/TAZ signaling.
The ability of cells to respond and adapt to different external mechanical stimuli converting them into biochemical signals falls under the name of mechanotransduction (Discher et al., 2009). Pivotal in such phenomenon are YAP and TAZ, transcriptional co-regulators whose activation is driven by nuclear accumulation triggered by external mechanical inputs (Dupont et al., 2011; Aragona et al., 2013; Piccolo et al., 2014; Zanconato et al., 2016). Despite extensive efforts, the molecular mechanisms regulating YAP/TAZ signaling are still debated. Recently, the mechanical continuum between the cytoskeleton and the nuclear envelope has emerged as fundamental element in YAP/TAZ mechanotransduction (Elosegui-Artola et al., 2017; Janota et al., 2020). Here, we set to investigate how nuclear envelope components and their connection with the cytoskeleton can impact on YAP/TAZ signaling.
Role of LINC complex in YAP/TAZ mechanotransduction
ALBANESE, CARLO JUNIOR
2023/2024
Abstract
The ability of cells to respond and adapt to different external mechanical stimuli converting them into biochemical signals falls under the name of mechanotransduction (Discher et al., 2009). Pivotal in such phenomenon are YAP and TAZ, transcriptional co-regulators whose activation is driven by nuclear accumulation triggered by external mechanical inputs (Dupont et al., 2011; Aragona et al., 2013; Piccolo et al., 2014; Zanconato et al., 2016). Despite extensive efforts, the molecular mechanisms regulating YAP/TAZ signaling are still debated. Recently, the mechanical continuum between the cytoskeleton and the nuclear envelope has emerged as fundamental element in YAP/TAZ mechanotransduction (Elosegui-Artola et al., 2017; Janota et al., 2020). Here, we set to investigate how nuclear envelope components and their connection with the cytoskeleton can impact on YAP/TAZ signaling.File | Dimensione | Formato | |
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https://hdl.handle.net/20.500.12608/71581