This study was conducted at the Neurophysiology Laboratory, IRCCS Centro San Giovanni di Dio Fatebenefratelli in Brescia. The objective involved the implementation and evaluation of a new method for reconstructing transcranial evoked potential sources. In contrast to traditional methods, the new approach integrates a priori information on grey matter regions structurally connected to the primary motor cortex, which is stimulated during the transcranial magnetic stimulation experiment. Due to technical constraints, it was not possible to use individual tractography data to reconstruct the networks of connections; therefore, an fMRI-DTI template of the sensorimotor network of the right hand in the resting state was adopted. The pilot study implemented two distinct approaches: • “A posteriori” method (traditional method): includes all grey matter in the sourcemodel and only then focuses on areas structurally connected to the primary motor cortex. • “A priori” method (new method): includes only the areas structurally, linked with the the primary motor cortex, in the source model. Analyses focused on four main aspects: (1) verification of the ‘A posteriori’ method, which confirmed the major activity in the network areas; (2) evaluation of the main effect of the methods, which showed similar performance within the brain network; (3) evaluation of the main effect of the ROIs (Region Of Interest), identifying significant differences between them; (4) evaluation of the ROI-method interaction, which revealed differences in the cerebellum results with the ‘A priori’ method. The ‘A priori’ method proved to be more sensitive in detecting the activation of cerebellar regions than the traditional method. Although the overall activation of the sensorimotor network was similar, the new approach showed a greater ability to localise specific cerebellar activations. This result underlines the potential of the ‘A priori’ method to improve understanding of brain networks and develop more targeted interventions, particularly useful for patients with alterations in anatomical structure or patterns of brain connectivity.
Implementation of a new TMS-EEG source reconstruction model using fMRI-DTI template as a prior: a comparative study with the state of the art.
CINELLI, SARA
2023/2024
Abstract
This study was conducted at the Neurophysiology Laboratory, IRCCS Centro San Giovanni di Dio Fatebenefratelli in Brescia. The objective involved the implementation and evaluation of a new method for reconstructing transcranial evoked potential sources. In contrast to traditional methods, the new approach integrates a priori information on grey matter regions structurally connected to the primary motor cortex, which is stimulated during the transcranial magnetic stimulation experiment. Due to technical constraints, it was not possible to use individual tractography data to reconstruct the networks of connections; therefore, an fMRI-DTI template of the sensorimotor network of the right hand in the resting state was adopted. The pilot study implemented two distinct approaches: • “A posteriori” method (traditional method): includes all grey matter in the sourcemodel and only then focuses on areas structurally connected to the primary motor cortex. • “A priori” method (new method): includes only the areas structurally, linked with the the primary motor cortex, in the source model. Analyses focused on four main aspects: (1) verification of the ‘A posteriori’ method, which confirmed the major activity in the network areas; (2) evaluation of the main effect of the methods, which showed similar performance within the brain network; (3) evaluation of the main effect of the ROIs (Region Of Interest), identifying significant differences between them; (4) evaluation of the ROI-method interaction, which revealed differences in the cerebellum results with the ‘A priori’ method. The ‘A priori’ method proved to be more sensitive in detecting the activation of cerebellar regions than the traditional method. Although the overall activation of the sensorimotor network was similar, the new approach showed a greater ability to localise specific cerebellar activations. This result underlines the potential of the ‘A priori’ method to improve understanding of brain networks and develop more targeted interventions, particularly useful for patients with alterations in anatomical structure or patterns of brain connectivity.File | Dimensione | Formato | |
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https://hdl.handle.net/20.500.12608/77845