This thesis focuses on the synthesis and characterization of polyoxometalate (POM) hybrids, particularly Wells-Dawson and Anderson-Evans structures, functionalized for biological applications. The study aims to explore the potential of these hybrids in inhibiting amyloid β-peptide aggregation, a hallmark of Alzheimer’s disease. Monofunctionalization strategies were employed to develop POM scaffolds compatible with peptides, such as QKLVFF. The work includes synthesizing lacunary POMs and mixed-addenda modifications to enhance reactivity. Advanced methods, including click chemistry, were applied to ensure selective conjugation of peptides, combining the redox properties of POMs with the recognition potential of peptides.
This thesis focuses on the synthesis and characterization of polyoxometalate (POM) hybrids, particularly Wells-Dawson and Anderson-Evans structures, functionalized for biological applications. The study aims to explore the potential of these hybrids in inhibiting amyloid β-peptide aggregation, a hallmark of Alzheimer’s disease. Monofunctionalization strategies were employed to develop POM scaffolds compatible with peptides, such as QKLVFF. The work includes synthesizing lacunary POMs and mixed-addenda modifications to enhance reactivity. Advanced methods, including click chemistry, were applied to ensure selective conjugation of peptides, combining the redox properties of POMs with the recognition potential of peptides.
Synthesis and characterization of bioconjugated polyoxometalates for biological applications
CERATO, EMANUELE
2023/2024
Abstract
This thesis focuses on the synthesis and characterization of polyoxometalate (POM) hybrids, particularly Wells-Dawson and Anderson-Evans structures, functionalized for biological applications. The study aims to explore the potential of these hybrids in inhibiting amyloid β-peptide aggregation, a hallmark of Alzheimer’s disease. Monofunctionalization strategies were employed to develop POM scaffolds compatible with peptides, such as QKLVFF. The work includes synthesizing lacunary POMs and mixed-addenda modifications to enhance reactivity. Advanced methods, including click chemistry, were applied to ensure selective conjugation of peptides, combining the redox properties of POMs with the recognition potential of peptides.File | Dimensione | Formato | |
---|---|---|---|
Emanuele_Cerato.pdf
accesso riservato
Dimensione
19.32 MB
Formato
Adobe PDF
|
19.32 MB | Adobe PDF |
The text of this website © Università degli studi di Padova. Full Text are published under a non-exclusive license. Metadata are under a CC0 License
https://hdl.handle.net/20.500.12608/80295