Castleman disease (CD) is defined as a heterogeneous group of lymphoproliferative disorders that share histopathologic features on lymph node biopsy. CD can be classified into distinct disorders that have different clinical features, treatments, and outcomes. It can be divided into unicentric CD (UCD), a form that involves one or more lymph nodes in a single region of the body, and multicentric CD (MCD) which involves lymph nodes of multiple regions and usually has systemic inflammatory symptoms. МСD is subclassified into ΗНV-8-associated МСD and idiopathic MCD depending on the presence of ΗΗV-8. This review will describe the latest evidence regarding the clinical manifestations, diagnosis and treatment of CD. A retrospective analysis was carried out on all the patients with CD evaluated in the Oncology Reference Center of Aviano from 1992 to 2024.
Castleman disease (CD) is defined as a heterogeneous group of lymphoproliferative disorders that share histopathologic features on lymph node biopsy. CD can be classified into distinct disorders that have different clinical features, treatments, and outcomes. It can be divided into unicentric CD (UCD), a form that involves one or more lymph nodes in a single region of the body, and multicentric CD (MCD) which involves lymph nodes of multiple regions and usually has systemic inflammatory symptoms. МСD is subclassified into ΗНV-8-associated МСD and idiopathic MCD depending on the presence of ΗΗV-8. This review will describe the latest evidence regarding the clinical manifestations, diagnosis and treatment of CD. A retrospective analysis was carried out on all the patients with CD evaluated in the Oncology Reference Center of Aviano from 1992 to 2024.
Castleman disease: a narrative review and retrospective analysis of the Oncology Reference Center of Aviano
PUTAGGIO, CRISTINA
2022/2023
Abstract
Castleman disease (CD) is defined as a heterogeneous group of lymphoproliferative disorders that share histopathologic features on lymph node biopsy. CD can be classified into distinct disorders that have different clinical features, treatments, and outcomes. It can be divided into unicentric CD (UCD), a form that involves one or more lymph nodes in a single region of the body, and multicentric CD (MCD) which involves lymph nodes of multiple regions and usually has systemic inflammatory symptoms. МСD is subclassified into ΗНV-8-associated МСD and idiopathic MCD depending on the presence of ΗΗV-8. This review will describe the latest evidence regarding the clinical manifestations, diagnosis and treatment of CD. A retrospective analysis was carried out on all the patients with CD evaluated in the Oncology Reference Center of Aviano from 1992 to 2024.File | Dimensione | Formato | |
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https://hdl.handle.net/20.500.12608/82015