This thesis investigates the impact of partial and heterogeneous detection on epidemic indicators in the context of outbreak analysis. Beginning with a deterministic SIR model, structured heterogeneity is introduced through contact-based risk classes, enabling a reformulation of key epidemiological quantities. The analysis is then extended to a stochastic network-based model, providing a more realistic account of variability, both in transmission dynamics and detection process. We examine how class-dependent detection probabilities distort observable trends, leading to significant bias in growth-based estimates. Correction strategies based on the spectral structure of the transmission process are developed and illustrated through deterministic simulations, and further explored within a stochastic setting to assess their qualitative robustness under realistic variability. The results support a robust and interpretable methodology for incorporating observational heterogeneity in epidemic assessment.

Biased epidemic analysis due to heterogenous and partial surveillance: a study on deterministic and stochastic multi-class models for epidemic dynamics

LUZZI, LORENZO
2024/2025

Abstract

This thesis investigates the impact of partial and heterogeneous detection on epidemic indicators in the context of outbreak analysis. Beginning with a deterministic SIR model, structured heterogeneity is introduced through contact-based risk classes, enabling a reformulation of key epidemiological quantities. The analysis is then extended to a stochastic network-based model, providing a more realistic account of variability, both in transmission dynamics and detection process. We examine how class-dependent detection probabilities distort observable trends, leading to significant bias in growth-based estimates. Correction strategies based on the spectral structure of the transmission process are developed and illustrated through deterministic simulations, and further explored within a stochastic setting to assess their qualitative robustness under realistic variability. The results support a robust and interpretable methodology for incorporating observational heterogeneity in epidemic assessment.
2024
Biased epidemic analysis due to heterogenous and partial surveillance: a study on deterministic and stochastic multi-class models for epidemic dynamics
Applied Mathematics
Epidemiology
Stochastic models
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12608/84810