Engineered 3D vascularized neuroblastoma tumor model in a fluidic chip for drug screening

Neuroblastoma remains one of the most aggressive pediatric cancers, with limited treatment options for high-risk patients. In this work, it is presented a vascularized tumor-on-a-chip model designed to mimic the tumor microenvironment of neuroblastoma, integrating NB spheroids and supporting vasculogenesis. The microfluidic platform enables real-time observation of tumor-vascular interactions and response to anti-angiogenic treatments. It is demonstrated the system's applicability by evaluating the effect of cancer cells on vascular network formation alongside tumor behavior. This model represents a promising tool for personalized drug testing and preclinical studies.