Performance Evaluation of a Surface-Guided Radiation Therapy (SGRT) System for Breast Cancer Treatment in Image-Guided Radiotherapy

Surface Guided Radiation Therapy (SGRT) systems are increasingly being integrated into clinical practice to enhance the precision and safety of breast irradiation treatments. This thesis presents a comprehensive evaluation of the performance of the AlignRT system, focusing on its accuracy, reproducibility, and clinical utility during patient setup and monitoring. Technical commissioning tests were performed to assess system accuracy under static and dynamic conditions. Clinical performance was evaluated by analyzing setup deviations measured by cone-beam computed tomography (CBCT) after SGRT-guided positioning in breast cancer patients. The work also examines the dosimetric impact of SGRT. This study was conducted at the San Bortolo Hospital in Vicenza, contributing to the growing body of evidence supporting the implementation of SGRT in breast cancer radiotherapy to optimize treatment accuracy, reduce setup margins, and minimize unnecessary radiation exposure.