Chronic inflammation is a key factor in the management of hemodialysis patients, contributing to the development of anemia and to an increased requirement for exogenous erythropoietin. The aim of this study was to evaluate the effect of vitamin E-coated dialyzers on the inflammatory profile and, in particular, on anemia in patients undergoing chronic hemodialysis. The results showed that the use of vitamin E-coated dialyzers was associated with a significant reduction in pro-inflammatory cytokines, a lower need for exogenous erythropoietin, and an improved control of hemoglobin levels. These findings suggest that vitamin E-coated dialyzers may represent an effective strategy to reduce systemic inflammation and optimize anemia management in hemodialysis patients, while maintaining the same dialytic efficiency as conventional filters.
L’infiammazione cronica è un fattore chiave nella gestione dei pazienti in emodialisi, contribuendo all’insorgenza dell’anemia ed all’aumento del fabbisogno di eritropoietina esogena. Lo scopo di questo studio è stato valutare l’impatto dei dializzatori vitamina E-coated sul quadro infiammatorio ed in particolar modo sull’anemia nei pazienti emodializzati cronici. I risultati hanno evidenziato una riduzione delle citochine pro-infiammatorie nei pazienti trattati con i bireattori rivestiti con vitamina E, accompagnata da una minore necessità di eritropoietina esogena e da un migliore controllo dell’anemia. Questi dati suggeriscono che i dializzatori vitamina E-coated possono rappresentare una strategia efficace per ridurre l’infiammazione ed ottimizzare la gestione dell’anemia nei pazienti in emodialisi, pur mantenendo la stessa efficacia dialitica di un filtro convenzionale.
L’ utilizzo di un bioreattore vitamina E-coated nella gestione dell’anemia nei pazienti emodializzati: l’esperienza congiunta dei centri dialisi di Padova e Rovigo.
MALAFRONTE, ALESSANDRA
2023/2024
Abstract
Chronic inflammation is a key factor in the management of hemodialysis patients, contributing to the development of anemia and to an increased requirement for exogenous erythropoietin. The aim of this study was to evaluate the effect of vitamin E-coated dialyzers on the inflammatory profile and, in particular, on anemia in patients undergoing chronic hemodialysis. The results showed that the use of vitamin E-coated dialyzers was associated with a significant reduction in pro-inflammatory cytokines, a lower need for exogenous erythropoietin, and an improved control of hemoglobin levels. These findings suggest that vitamin E-coated dialyzers may represent an effective strategy to reduce systemic inflammation and optimize anemia management in hemodialysis patients, while maintaining the same dialytic efficiency as conventional filters.| File | Dimensione | Formato | |
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Tesi ufficiale.pdf
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https://hdl.handle.net/20.500.12608/96955