Purpose or Learning Objective: The left atrioventricular coupling index (LACI), defined as the end-diastolic left atrial to ventricular volume ratio, is a marker of diastolic dysfunction linked to poor prognosis. This study evaluates the concordance of LACI assessment by transthoracic echocardiography and cardiac magnetic resonance in patients with heart failure with reduced ejection fraction (HREF) and patients with cardiac amyloidosis (CA). Methods or Background: A total of 152 patients were retrospectively enrolled, including 34 with HREF and 118 with CA. All patients underwent both echocardiographic examination and CMR imaging (1.5T). Results or Findings: LACI values were significative higher in the amyloidosis population with both TTE [18.55 (13.65-32.43) vs 62.83 (±22.06)] and CMR [16.59 (13.29-24.69) vs 51.85 (±19.95)] as expected (all p<0,05). The ICC was 0.86 (95% CI: 0.68–0.82). Bland–Altman analysis showed a mean bias of 8.6 units (95% CI: 8.57). Conclusion: there’s a good agreement between TTE and CMR with a tendency of TTE to overestimate volumes for both groups, especially for the amyloidosis population. Limitations: monocentric, single observer study.
Scopo o Obiettivo formativo: L'indice di accoppiamento atrioventricolare sinistro (LACI), definito come il rapporto tra il volume atriale sinistro e il volume ventricolare sinistro in telediastole, è un marcatore di disfunzione diastolica associato a una prognosi sfavorevole. Questo studio valuta la concordanza nella misurazione del LACI mediante ecocardiografia transtoracica (TTE) e risonanza magnetica cardiaca (CMR) in pazienti con scompenso cardiaco a frazione di eiezione ridotta (HFrEF) e in pazienti con amiloidosi cardiaca (CA). Metodi o Contesto: Sono stati arruolati retrospettivamente un totale di 152 pazienti, di cui 34 con HFrEF e 118 con CA. Tutti i pazienti sono stati sottoposti sia a ecocardiografia che a CMR (1.5 Tesla). Risultati o Evidenze: I valori di LACI sono risultati significativamente più elevati nella popolazione con amiloidosi, sia con TTE [18,55 (13,65–32,43) vs 62,83 (±22,06)] sia con CMR [16,59 (13,29–24,69) vs 51,85 (±19,95)], come atteso (tutti p < 0,05). L'ICC (coefficiente di correlazione intraclasse) era 0,86 (IC 95%: 0,68–0,82). L’analisi di Bland–Altman ha mostrato un bias medio di 8,6 unità (IC 95%: 8,57). Conclusione: Esiste una buona concordanza tra TTE e CMR, con una tendenza della TTE a sovrastimare i volumi in entrambi i gruppi, in particolare nella popolazione con amiloidosi. Limitazioni: Studio monocentrico, condotto da un singolo osservatore.
Valutazione comparativa dell'indice di accoppiamento atriale sinistro mediante risonanza magnetica e ecocardiografia nello scompenso cardiaco.
BINI, COSTANZA
2023/2024
Abstract
Purpose or Learning Objective: The left atrioventricular coupling index (LACI), defined as the end-diastolic left atrial to ventricular volume ratio, is a marker of diastolic dysfunction linked to poor prognosis. This study evaluates the concordance of LACI assessment by transthoracic echocardiography and cardiac magnetic resonance in patients with heart failure with reduced ejection fraction (HREF) and patients with cardiac amyloidosis (CA). Methods or Background: A total of 152 patients were retrospectively enrolled, including 34 with HREF and 118 with CA. All patients underwent both echocardiographic examination and CMR imaging (1.5T). Results or Findings: LACI values were significative higher in the amyloidosis population with both TTE [18.55 (13.65-32.43) vs 62.83 (±22.06)] and CMR [16.59 (13.29-24.69) vs 51.85 (±19.95)] as expected (all p<0,05). The ICC was 0.86 (95% CI: 0.68–0.82). Bland–Altman analysis showed a mean bias of 8.6 units (95% CI: 8.57). Conclusion: there’s a good agreement between TTE and CMR with a tendency of TTE to overestimate volumes for both groups, especially for the amyloidosis population. Limitations: monocentric, single observer study.| File | Dimensione | Formato | |
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https://hdl.handle.net/20.500.12608/97565