Coupling of polymeric brushes functionalized with RGD peptide on PCL surfaces to increase cell adhesion

Osteoarthritis is a complex disease referring to the degeneration of articular cartilage, which has poor intrinsic capacity of self-regeneration. In order to find a way to create a construct able to replace and regenerate this particular tissue, a functionalized biodegradable polymer via polymer brushes can represent a design for cartilage loss. The aim of this work is the study of the functionalization of a biodegradable polymer (PCL) surface with RGD peptide via PNIPAM brushes