Exploring the relationship between multi-scale functional dynamics and cerebral protein synthesis measured with L-[1-11C]Leucine PET

The relationship between regional protein synthesis and on-going neural dynamics is still unclear. We used a graph theoretical approach, to examine the relationship between functional connectivity (measured using Resting-State fMRI) and the rate of cerebral protein synthesis (rCPS). We found a significant relationship between the two; the association appears to be dependent to the temporal scale of fMRI signal, and independent from tissue metabolism