Optimal design of a minimum set of clinical tests for the identification and characterization of Von Willebrand disease

Von Willebrand disease (VWD) is one of the most common bleeding disorders visible in humans, caused by qualitative or quantitative deficiencies of von Willebrand factor (VWF), a multimeric glycoprotein fundamental in the coagulation process. The overall objective of this project is to optimally design a minimal set of basal clinical tests for the identification of the PK model of VWD in order to decrease the time and effort required for disease characterization and diagnosis