The thesis project is based on the synthesis and characterization of drug functionalized antibodies and biotinylated products for conjugation to poly-avidin systems (ANANAS). The synthesis protocols are optimized and in vitro cell trafficking studies carried out prior to an in vivo study on therapeutic efficacy against HER positive tumors.
Il progetto di tesi si basa sulla sintesi e caratterizzazione di anticorpi farmaco funzionalizzati e prodotti biotinilati per la coniugazione a sistemi di poli-avidina (ANANAS). Vengono ottimizzati i protocolli di sintesi ed effettuati studi in vitro di traffico cellulare preliminarmente ad uno studio in vivo sull’efficacia terapeutica contro tumori HER positivi.
Formulazione e caratterizzazione di sistemi poli-avidina e coniugati farmaco anticorpo direzionati contro tumori HER positivi
DARIZ, CRISTIAN
2021/2022
Abstract
The thesis project is based on the synthesis and characterization of drug functionalized antibodies and biotinylated products for conjugation to poly-avidin systems (ANANAS). The synthesis protocols are optimized and in vitro cell trafficking studies carried out prior to an in vivo study on therapeutic efficacy against HER positive tumors.| File | Dimensione | Formato | |
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Dariz_Cristian.pdf
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https://hdl.handle.net/20.500.12608/42400