Depression is one of the most common pathologies in the world manifesting with more or less serious symptoms, such as anxiety, panic attacks, insomnia, loss of interest, anhedonia and sometimes suicidal thoughts. The complexity and the heterogeneity of this mood disorder make its diagnosis and treatment difficult. The treatment is currently based on pharmacological therapy and psychotherapy. The same goes for bipolar disorder, a chronic psychiatric disorder characterized by depressive and hypomanic/manic episodes (periods of euphoric mood with talkativeness, megalomania, disinhibition), which alternate with periods of well-being. In this study, the variation in the levels of some neurotransmitters belonging to tryptophan metabolism was evaluated starting from plasma samples of patients affected by these mood disorders. In particular, tryptophan was analyzed using the HPLC technique, together with the metabolites of the two metabolic pathways, the kynurenine pathway and the serotonin pathway.
La depressione è una delle patologie più comuni al mondo e si manifesta con sintomi più o meno gravi, come ansia, attacchi di panico, insonnia, perdita di interesse o piacere e talvolta pensieri suicidi. La complessità e l’eterogeneità di questo disturbo dell’umore ne rendono difficile la diagnosi e il trattamento, ad oggi basato sulla terapia farmacologica e sulla psicoterapia. Lo stesso vale per il disturbo bipolare, un disturbo psichiatrico cronico caratterizzato da episodi depressivi e ipomaniacali/maniacali (periodi di umore euforico con logorrea, megalomania, disinibizione), alternati a intervalli di benessere. In questo studio è stata valutata la variazione dei livelli di alcuni neurotrasmettitori appartenenti al metabolismo del triptofano a partire da campioni di plasma di pazienti affetti da questi disturbi dell’umore. In particolare, utilizzando la tecnica HPLC è stato analizzato il triptofano, insieme ai metaboliti delle due vie metaboliche, la via della chinurenina e la via della serotonina.
Correlazione tra metabolismo del triptofano e patofisiologia in pazienti affetti da disturbo bipolare e depressione maggiore
MENIN, ELISA
2022/2023
Abstract
Depression is one of the most common pathologies in the world manifesting with more or less serious symptoms, such as anxiety, panic attacks, insomnia, loss of interest, anhedonia and sometimes suicidal thoughts. The complexity and the heterogeneity of this mood disorder make its diagnosis and treatment difficult. The treatment is currently based on pharmacological therapy and psychotherapy. The same goes for bipolar disorder, a chronic psychiatric disorder characterized by depressive and hypomanic/manic episodes (periods of euphoric mood with talkativeness, megalomania, disinhibition), which alternate with periods of well-being. In this study, the variation in the levels of some neurotransmitters belonging to tryptophan metabolism was evaluated starting from plasma samples of patients affected by these mood disorders. In particular, tryptophan was analyzed using the HPLC technique, together with the metabolites of the two metabolic pathways, the kynurenine pathway and the serotonin pathway.File | Dimensione | Formato | |
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https://hdl.handle.net/20.500.12608/43059