Schizophrenia is a complex psychosis, impairing numerous physiological and functional areas of affected individuals. Following an initial introduction of the disorder and its various pathological and diagnostic aspects, the paper focuses on the analysis of potential genetic contributions to the disorder itself. Various behavioural and molecular genetic studies emerge from the existing literature. Behavioural genetics studies, carried out on families and children (both twins and adopted children), are more convincing because they are well replicated. Molecular genetic studies, on the other hand, reveal the identification of several genes and mutations that can potentially be linked to the onset of the disease in affected individuals. Supporting research includes studies by workers on animal samples (rodents) as well as GWAS (Genome Wide Association) studies.
La schizofrenia è una psicosi complessa, compromettente numerose aree fisiologiche e funzionali degli individui che ne sono affetti. In seguito ad un'iniziale introduzione del disturbo e dei vari aspetti patologici e diagnostici, l'elaborato si focalizza sull'analisi dei potenziali contributi genetici al disturbo stesso. Dalla letteratura esistente emergono diversi studi di genetica comportamentale e molecolare. Gli studi di genetica del comportamento, svolti su famiglie e figli (sia gemelli che figli adottati), risultano più convincenti perchè ben replicati. Dagli studi di genetica molecolare emerge invece l'individuazione di diversi geni e mutazioni potenzialmente collegabili all'insorgenza della malattia in individui affetti. Tra le ricerche a sostegno troviamo, oltre che alcuni studi di lavoratori su campioni animali (roditori), anche studi di GWAS (Genome Wide Association).
Contributo Genetico alla Schizofrenia
MELDI, BEATRICE
2022/2023
Abstract
Schizophrenia is a complex psychosis, impairing numerous physiological and functional areas of affected individuals. Following an initial introduction of the disorder and its various pathological and diagnostic aspects, the paper focuses on the analysis of potential genetic contributions to the disorder itself. Various behavioural and molecular genetic studies emerge from the existing literature. Behavioural genetics studies, carried out on families and children (both twins and adopted children), are more convincing because they are well replicated. Molecular genetic studies, on the other hand, reveal the identification of several genes and mutations that can potentially be linked to the onset of the disease in affected individuals. Supporting research includes studies by workers on animal samples (rodents) as well as GWAS (Genome Wide Association) studies.File | Dimensione | Formato | |
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https://hdl.handle.net/20.500.12608/47136