The activation of innate immunity through the stimulation of the STING pathway is a possible way to limit tumor progression. The transmembrane protein STING placed in the endoplasmic reticulum and activated by the cyclic dinucleotide cGAMP is able to stimulate the production of type I Interferons, and to activate both the innate and the adaptive immunity through NK cells and CD8+ lymphocytes. Normally activated in response to viral or bacterial infections, STING can also be activated in response to neoplastic proliferation. Research is mainly focusing on the activation of the pathway through the administration of synthetic agonists which potently induce the intracellular signaling pathway and stimulate the immune response so as to allow the control of different types of tumors in mice. This ability combined with cell therapy undoubtedly represents a breakthrough in the clinical treatment of neoplasms.
L'attivazione dell'immunità innata attraverso la stimolazione dello STING pathway si configura come una possibile via per limitare la progressione tumorale. La proteina transmembrana STING collocata nel reticolo endoplasmatico e attivata dal dinucleotide ciclico cGAMP è in grado di stimolare la produzione di Interferoni di tipo I, e di attivare l'immunità innata tramite le cellule NK e l'immunità acquisita con i linfociti CD8+. Normalmente attivata in seguito a infezioni virali o batteriche, può essere attivata anche in risposta alla proliferazione neoplastica. La ricerca si sta concentrando soprattutto sull'attivazione del pathway attraverso la somministrazione di agonisti sintetici che inducono in modo potente la via di segnalazione intracellulare e stimolano la risposta immunitaria tanto da permettere il controllo di diversi tipi di tumori nel topo. Questa capacità combinata con la terapia cellulare rappresenta senza dubbio una svolta nel trattamento clinico delle neoplasie.
ROLE OF THE CGAS-STING PATHWAY IN CANCER IMMUNITY AND IMMUNOTHERAPY: THE STING PATHWAY COMBINED WITH CELL THERAPY
DELFINO, FEDERICA
2022/2023
Abstract
The activation of innate immunity through the stimulation of the STING pathway is a possible way to limit tumor progression. The transmembrane protein STING placed in the endoplasmic reticulum and activated by the cyclic dinucleotide cGAMP is able to stimulate the production of type I Interferons, and to activate both the innate and the adaptive immunity through NK cells and CD8+ lymphocytes. Normally activated in response to viral or bacterial infections, STING can also be activated in response to neoplastic proliferation. Research is mainly focusing on the activation of the pathway through the administration of synthetic agonists which potently induce the intracellular signaling pathway and stimulate the immune response so as to allow the control of different types of tumors in mice. This ability combined with cell therapy undoubtedly represents a breakthrough in the clinical treatment of neoplasms.File | Dimensione | Formato | |
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https://hdl.handle.net/20.500.12608/50087