The thesis is part of the ISOLPHARM project, whose aim is the production of high-purity radioisotopes for use in both diagnostic and therapeutic nuclear medicine applications by utilizing the second-generation ISOL facility, SPES (Selective Production of Exotic Species). More specifically, the thesis focuses on using the Geant4-DNA simulation toolkit, an extension of Geant4, to investigate the potential DNA damage caused by radiation coming from sources of 111Ag and 60Co. Results are fundamental for the experiment ISOLPHARM-ADMIRAL, whose objective is the evaluation of the diagnostic and therapeutic power of radiopharmaceuticals containing the innovative radionuclide 111Ag.

The thesis is part of the ISOLPHARM project, whose aim is the production of high-purity radioisotopes for use in both diagnostic and therapeutic nuclear medicine applications by utilizing the second-generation ISOL facility, SPES (Selective Production of Exotic Species). More specifically, the thesis focuses on using the Geant4-DNA simulation toolkit, an extension of Geant4, to investigate the potential DNA damage caused by radiation coming from sources of 111Ag and 60Co. Results are fundamental for the experiment ISOLPHARM-ADMIRAL, whose objective is the evaluation of the diagnostic and therapeutic power of radiopharmaceuticals containing the innovative radionuclide 111Ag.

Study of DNA damage by beta radiation using GEANT4-DNA in the context of the ISOLPHARM project

LESO, AURORA
2022/2023

Abstract

The thesis is part of the ISOLPHARM project, whose aim is the production of high-purity radioisotopes for use in both diagnostic and therapeutic nuclear medicine applications by utilizing the second-generation ISOL facility, SPES (Selective Production of Exotic Species). More specifically, the thesis focuses on using the Geant4-DNA simulation toolkit, an extension of Geant4, to investigate the potential DNA damage caused by radiation coming from sources of 111Ag and 60Co. Results are fundamental for the experiment ISOLPHARM-ADMIRAL, whose objective is the evaluation of the diagnostic and therapeutic power of radiopharmaceuticals containing the innovative radionuclide 111Ag.
2022
Study of DNA damage by beta radiation using GEANT4-DNA in the context of the ISOLPHARM project
The thesis is part of the ISOLPHARM project, whose aim is the production of high-purity radioisotopes for use in both diagnostic and therapeutic nuclear medicine applications by utilizing the second-generation ISOL facility, SPES (Selective Production of Exotic Species). More specifically, the thesis focuses on using the Geant4-DNA simulation toolkit, an extension of Geant4, to investigate the potential DNA damage caused by radiation coming from sources of 111Ag and 60Co. Results are fundamental for the experiment ISOLPHARM-ADMIRAL, whose objective is the evaluation of the diagnostic and therapeutic power of radiopharmaceuticals containing the innovative radionuclide 111Ag.
Radiobiology
GEANT4-DNA
ISOLPHARM
Ag-111
Cellular dosimetry
Lauree magistrali
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12608/51895