This thesis is part of the ISOLPHARM project, aimed at exploiting the beams of radioactive atoms produced by the ISOL technology available at INFN-LNL to produce high purity radionuclides, useful for applications in nuclear medicine. Among the fundamental tools of this branch of medicine there are radiopharmaceuticals, pharmaceutical preparations that include radionuclides, whose radiation emitted can perform a diagnostic or therapeutic function. In this context, the thesis project focuses on the development of a solid support defined as a deposition target on which the radionuclides transported by the ISOL beam are collected. First, the materials created in previous works were optimized: direct compression mixtures based on cellulose and sugars; subsequently innovative target production methods were developed, based on the "solution casting" and "freeze and thaw" techniques. The objective was to obtain formulations with better characteristics than those of the targets currently available in terms of mechanical properties and compatibility with the ISOL machine. All the materials developed were compatible from a technological and mechanical point of view and the compatibility with different metal ions was verified, to identify the target with better characteristics for the application in ISOLPHARM.
Questo elaborato di tesi si inserisce nell’ambito del progetto ISOLPHARM, finalizzato a sfruttare i fasci di atomi radioattivi prodotti mediante la tecnologia ISOL disponibile presso INFN-LNL per produrre radionuclidi a elevata purezza, utili per applicazioni in medicina nucleare. Tra gli strumenti fondamentali di tale branca della medicina figurano i radiofarmaci, preparazioni farmaceutiche che includono radionuclidi, le cui radiazioni emesse possono svolgere una funzione diagnostica o terapeutica. In questo contesto, Il progetto di tesi è incentrato sullo sviluppo di un supporto solido definito target di deposizione sul quale sono collezionati i radionuclidi trasportati dal fascio ISOL. Dapprima sono stati perfezionati i materiali realizzati in lavori precedenti, ovvero miscele per compressione diretta a base di cellulosa e zuccheri, successivamente sono stati sviluppati innovativi metodi di produzione dei bersagli, basati sulle tecniche “solution casting” e “freeze and thaw”. L’obiettivo è stato di ottenere formulati aventi caratteristiche migliori rispetto a quelle dei target attualmente disponibili in termini di proprietà meccaniche e compatibilità con la macchina ISOL. Tutti i materiali sviluppati sono stati caratterizzati dal punto di vista tecnologico e meccanico ed è stata verificata la compatibilità con diversi ioni metallici, al fine di identificare il target con caratteristiche più promettenti per l’applicazione in ISOLPHARM.
Screening e sviluppo tecnologico di target di deposizione innovativi per la raccolta di radionuclidi medicali nell’ambito del progetto ISOLPHARM
NICENTE, FRANCESCA
2023/2024
Abstract
This thesis is part of the ISOLPHARM project, aimed at exploiting the beams of radioactive atoms produced by the ISOL technology available at INFN-LNL to produce high purity radionuclides, useful for applications in nuclear medicine. Among the fundamental tools of this branch of medicine there are radiopharmaceuticals, pharmaceutical preparations that include radionuclides, whose radiation emitted can perform a diagnostic or therapeutic function. In this context, the thesis project focuses on the development of a solid support defined as a deposition target on which the radionuclides transported by the ISOL beam are collected. First, the materials created in previous works were optimized: direct compression mixtures based on cellulose and sugars; subsequently innovative target production methods were developed, based on the "solution casting" and "freeze and thaw" techniques. The objective was to obtain formulations with better characteristics than those of the targets currently available in terms of mechanical properties and compatibility with the ISOL machine. All the materials developed were compatible from a technological and mechanical point of view and the compatibility with different metal ions was verified, to identify the target with better characteristics for the application in ISOLPHARM.File | Dimensione | Formato | |
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https://hdl.handle.net/20.500.12608/62059