Per- and Poly-fluoroalkyl substances (PFAS) have been an amazing industrial invention used for a wide range of daily products. Recent health-related discoveries have raised concerns that these molecules are persistent in the environment because they are not degraded naturally, so remediation solutions are needed. In this thesis, two possible enzyme candidates for PFAS biodegradation have been considered, namely dehalogenases and laccases, which are studied by bioinformatic approach to investigate whether they can be of help to PFAS degradation. Therefore, a comparative analysis of these enzymes was performed in microorganisms capable to live and grow in high PFAS concentrations.
Per- and Poly-fluoroalkyl substances (PFAS) have been an amazing industrial invention used for a wide range of daily products. Recent health-related discoveries have raised concerns that these molecules are persistent in the environment because they are not degraded naturally, so remediation solutions are needed. In this thesis, two possible enzyme candidates for PFAS biodegradation have been considered, namely dehalogenases and laccases, which are studied by bioinformatic approach to investigate whether they can be of help to PFAS degradation. Therefore, a comparative analysis of these enzymes was performed in microorganisms capable to live and grow in high PFAS concentrations.
A Computational Approach to PFAS Bioremediation: Comparative Analyses of Dehalogenases and Laccases Enzymes - an iGEM Project
SALMASO, SABRINA
2023/2024
Abstract
Per- and Poly-fluoroalkyl substances (PFAS) have been an amazing industrial invention used for a wide range of daily products. Recent health-related discoveries have raised concerns that these molecules are persistent in the environment because they are not degraded naturally, so remediation solutions are needed. In this thesis, two possible enzyme candidates for PFAS biodegradation have been considered, namely dehalogenases and laccases, which are studied by bioinformatic approach to investigate whether they can be of help to PFAS degradation. Therefore, a comparative analysis of these enzymes was performed in microorganisms capable to live and grow in high PFAS concentrations.| File | Dimensione | Formato | |
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https://hdl.handle.net/20.500.12608/67702