BACKGROUND: periodontal disease is a chronic multifactorial inflammatory condition that has a prevalence of 1.1 billion individuals. Caused by oral dysbiosis, these pathogenic bacteria have the ability to migrate to other anatomical districts distant from the oral cavity. For this reason, according to several epidemiological studies, periodontitis has been associated with various systemic disorders, including neoplasms. AIM OF THE STUDY: the aim of this thesis is to evaluate whether periodontal disease could be a potential risk factor for the onset of breast cancer through a systematic review of the literature. MATERIALS AND METHODS: the selection of literature studies was carried out by consulting PubMed, Google Scholar and Embase, detecting all articles from 2013 to 2023. The studies examined had to reflect certain eligibility criteria and their quality was assessed with the Newcastle-Ottawa scale. The PRISMA guidelines were followed for the drafting of the paper and a meta-analysis was subsequently performed using the Cochrane’s software ReviewManager (RevMan) and the effects were reported as risk ratio (RR) and 95% confidence intervals (CI). RESULTS: a total of 7 studies were included in this research, which investigated the occurrence of breast cancer in women with and without periodontal disease. Through the execution of a Forest Plot, an RR = 1.14 was identified; 95% CI = 1.08-1.20 such as to hypothesize a possible 14% increase in the incidence of breast cancer in patients with periodontitis. CONCLUSION: this study showed that periodontal disease could be considered a potential risk factor for breast cancer but, since there are limited studies in the literature, further investigations are needed to better understand this topic.
INTRODUZIONE: la malattia parodontale è una condizione infiammatoria cronica multifattoriale che presenta una prevalenza di 1.1 miliardi di individui. Causata da una disbiosi orale, tali batteri patogeni che la caratterizzano hanno la capacità di migrare in altri distretti anatomici distanti dalla cavità orale. Per questo motivo secondo diversi studi epidemiologici, la parodontite è stata associata a vari disturbi sistemici, tra cui le neoplasie. SCOPO DELLO STUDIO: lo scopo della presente tesi è quello di valutare se la malattia parodontale possa essere un potenziale fattore di rischio per l’insorgenza del carcinoma mammario attraverso una revisione sistematica della letteratura. MATERIALI E METODI: la selezione degli studi di letteratura è stata effettuata attraverso la consultazione di PubMed, Google Scholar ed Embase rilevando tutti gli articoli dal 2013 al 2023. Gli studi presi in esame dovevano rispecchiare determinati criteri di ammissibilità e la loro qualità è stata valutata con la scala Newcastle-Ottawa. Per la stesura dell’elaborato sono state seguite le linee guida PRISMA ed è stata successivamente effettuata una meta-analisi utilizzando il software ReviewManager (RevMan) di Cochrane e gli effetti sono stati riportati come risk ratio (RR) ed intervalli di confidenza (CI) al 95%. RISULTATI: in questa ricerca sono stati inclusi un totale di 7 studi, i quali hanno investigato l’insorgenza di tumore al seno in donne con e senza la malattia parodontale. Mediante l’esecuzione di un Forest Plot è stato individuato un RR = 1.14; 95% CI = 1.08-1.20 tale da ipotizzare un possibile aumento del 14% d’incidenza di carcinoma mammario in pazienti con parodontite. CONCLUSIONE: da questo studio è emerso che la malattia parodontale potrebbe essere considerata un potenziale fattore di rischio per il carcinoma mammario ma, essendoci studi limitati in letteratura, sono necessarie ulteriori indagini per approfondire meglio tale argomento.
La malattia parodontale come potenziale fattore di rischio per il carcinoma mammario: revisione sistematica della letteratura
CELLI, RICCARDO
2023/2024
Abstract
BACKGROUND: periodontal disease is a chronic multifactorial inflammatory condition that has a prevalence of 1.1 billion individuals. Caused by oral dysbiosis, these pathogenic bacteria have the ability to migrate to other anatomical districts distant from the oral cavity. For this reason, according to several epidemiological studies, periodontitis has been associated with various systemic disorders, including neoplasms. AIM OF THE STUDY: the aim of this thesis is to evaluate whether periodontal disease could be a potential risk factor for the onset of breast cancer through a systematic review of the literature. MATERIALS AND METHODS: the selection of literature studies was carried out by consulting PubMed, Google Scholar and Embase, detecting all articles from 2013 to 2023. The studies examined had to reflect certain eligibility criteria and their quality was assessed with the Newcastle-Ottawa scale. The PRISMA guidelines were followed for the drafting of the paper and a meta-analysis was subsequently performed using the Cochrane’s software ReviewManager (RevMan) and the effects were reported as risk ratio (RR) and 95% confidence intervals (CI). RESULTS: a total of 7 studies were included in this research, which investigated the occurrence of breast cancer in women with and without periodontal disease. Through the execution of a Forest Plot, an RR = 1.14 was identified; 95% CI = 1.08-1.20 such as to hypothesize a possible 14% increase in the incidence of breast cancer in patients with periodontitis. CONCLUSION: this study showed that periodontal disease could be considered a potential risk factor for breast cancer but, since there are limited studies in the literature, further investigations are needed to better understand this topic.| File | Dimensione | Formato | |
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https://hdl.handle.net/20.500.12608/76415