Parkinson's Disease (PD) is primarily known for its motor symptoms, but cognitive impairments, particularly Mild Cognitive Impairment (MCI), are also significant. This thesis focuses on MCI in PD, with a specific emphasis on working memory—a crucial cognitive function for temporarily holding and manipulating information. Working memory deficits in PD can severely affect daily life, from maintaining conversations to executing tasks. This literature review explores the prevalence and characteristics of working memory impairments in PD, noting that 20-50% of individuals with PD develop MCI, with working memory frequently impacted (Litvan et al., 2012). The neurobiological basis of these deficits is examined, focusing on the degeneration of dopaminergic neurons and the disruption of frontostriatal circuits critical for working memory (Owen, 2004). We review diagnostic methods, highlighting the use of neuropsychological tests like the Digit Span and n-back tasks, which, while useful, often lack sensitivity in distinguishing MCI from normal aging (Dalrymple-Alford et al., 2011). Treatment strategies, including dopaminergic medications such as Levodopa, show mixed results, while cognitive training programs offer potential but require further validation (Cools et al., 2001; Sammer et al., 2006). The thesis also identifies gaps in current research, advocating for longitudinal studies and the development of more sensitive diagnostic tools. Future research should integrate neuroimaging with cognitive assessments to better understand and address working memory dysfunction in PD.
Parkinson's Disease (PD) is primarily known for its motor symptoms, but cognitive impairments, particularly Mild Cognitive Impairment (MCI), are also significant. This thesis focuses on MCI in PD, with a specific emphasis on working memory—a crucial cognitive function for temporarily holding and manipulating information. Working memory deficits in PD can severely affect daily life, from maintaining conversations to executing tasks. This literature review explores the prevalence and characteristics of working memory impairments in PD, noting that 20-50% of individuals with PD develop MCI, with working memory frequently impacted (Litvan et al., 2012). The neurobiological basis of these deficits is examined, focusing on the degeneration of dopaminergic neurons and the disruption of frontostriatal circuits critical for working memory (Owen, 2004). We review diagnostic methods, highlighting the use of neuropsychological tests like the Digit Span and n-back tasks, which, while useful, often lack sensitivity in distinguishing MCI from normal aging (Dalrymple-Alford et al., 2011). Treatment strategies, including dopaminergic medications such as Levodopa, show mixed results, while cognitive training programs offer potential but require further validation (Cools et al., 2001; Sammer et al., 2006). The thesis also identifies gaps in current research, advocating for longitudinal studies and the development of more sensitive diagnostic tools. Future research should integrate neuroimaging with cognitive assessments to better understand and address working memory dysfunction in PD.
Exploring Mild Cognitive Impairment in Parkinson's Disease: A Comprehensive Review with a Focus on Working Memory
ATMACA, GIZEM CAN
2023/2024
Abstract
Parkinson's Disease (PD) is primarily known for its motor symptoms, but cognitive impairments, particularly Mild Cognitive Impairment (MCI), are also significant. This thesis focuses on MCI in PD, with a specific emphasis on working memory—a crucial cognitive function for temporarily holding and manipulating information. Working memory deficits in PD can severely affect daily life, from maintaining conversations to executing tasks. This literature review explores the prevalence and characteristics of working memory impairments in PD, noting that 20-50% of individuals with PD develop MCI, with working memory frequently impacted (Litvan et al., 2012). The neurobiological basis of these deficits is examined, focusing on the degeneration of dopaminergic neurons and the disruption of frontostriatal circuits critical for working memory (Owen, 2004). We review diagnostic methods, highlighting the use of neuropsychological tests like the Digit Span and n-back tasks, which, while useful, often lack sensitivity in distinguishing MCI from normal aging (Dalrymple-Alford et al., 2011). Treatment strategies, including dopaminergic medications such as Levodopa, show mixed results, while cognitive training programs offer potential but require further validation (Cools et al., 2001; Sammer et al., 2006). The thesis also identifies gaps in current research, advocating for longitudinal studies and the development of more sensitive diagnostic tools. Future research should integrate neuroimaging with cognitive assessments to better understand and address working memory dysfunction in PD.File | Dimensione | Formato | |
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https://hdl.handle.net/20.500.12608/78588