Investigating the Efficacy of the Crohn’s Disease Exclusion Diet in Pediatric Patients

This thesis explores the therapeutic potential of the Crohn’s Disease Exclusion Diet (CDED) in paediatric patients, combining a review of current literature with an in-depth case study. The primary objective was to better understand the physiological, microbial, and immunological mechanisms through which CDED contributes to disease remission, and to identify factors that may explain the enhanced response observed in children compared to adults. Findings from the literature suggest that CDED may help restore intestinal barrier integrity, modulate dysbiotic microbiota, and reduce mucosal inflammation. These mechanisms are supported by both clinical and experimental data, though further research is needed to clarify causal relationships. The case study illustrated the practical implementation of CDED over a five-year period, highlighting the critical role of long-term adherence, family support, and structured follow-up in achieving sustained remission and normal growth. The results underscore the value of dietary therapy as an adjunct to pharmacological treatment in paediatric Crohn’s disease (CD). While the evidence is promising, especially in children, future research should focus not only on confirming long-term outcomes but also on strategies to improve adherence across different patient populations, as the diet itself appears broadly effective when followed consistently.