Obsessive-Compulsive Disorder (OCD) is a neuropsychiatric disorder characterized by long-term recurring thoughts, known as obsessions, and/or compulsive behaviors. This paper presents several promising research studies investigating the application of EEG in the diagnosis of OCD; however, these studies are still in the experimental phase. In one of the proposed applications, EEG features were analyzed to evaluate their diagnostic potential for OCD and to differentiate patients with OCD from healthy individuals. The results suggest that the EEG feature based on functional connectivity, the Phase-Locking Value (PLV), shows strong potential as a biomarker for OCD. In another application, the effectiveness of transcranial direct current stimulation (tDCS) as a treatment for OCD patients was investigated through the acquisition of measurements using transcranial magnetic stimulation combined with electroencephalography (TMS-EEG). The results obtained following tDCS treatment were positive, indicating it as a potential treatment option for OCD patients; it may also be suitable for individuals with treatment-resistant OCD.
Il disturbo ossessivo-compulsivo è un disturbo neuropsichiatrico caratterizzato da pensieri ricorrenti nel lungo periodo, ovvero le ossessioni, e/o attività compulsive. Questo elaborato presenta alcuni studi di ricerca promettenti che indagano l’applicazione dell’EEG per la diagnosi dell’OCD; tuttavia, essi si trovano ancora in fase di sperimentazione. In una delle applicazioni proposte sono state analizzate caratteristiche EEG, per valutarne la capacità diagnostica del disturbo ossessivo-compulsivo e discriminare i pazienti con OCD da quelli sani. I risultati ottenuti suggeriscono che la caratteristica EEG basata sulla connettività funzionale, il PLV, mostra un elevato potenziale come biomarcatore dell'OCD. Nell'altra applicazione è stata investigata l’efficacia del trattamento con stimolazione transcranica a corrente continua (tDCS) nei pazienti con OCD, attraverso l’acquisizione di misure con l’applicazione della stimolazione magnetica transcranica combinata con l’elettroencefalografia (TMS-EEG). I risultati ottenuti in seguito al trattamento con tDCS sono stati positivi, tanto da rappresentare un possibile trattamento per i pazienti con OCD; esso potrebbe essere indicato anche per i pazienti con OCD resistenti alle terapie tradizionali.
L’elettroencefalogramma come strumento di studio del disturbo ossessivo-compulsivo
MANUSHI, NEVILA
2024/2025
Abstract
Obsessive-Compulsive Disorder (OCD) is a neuropsychiatric disorder characterized by long-term recurring thoughts, known as obsessions, and/or compulsive behaviors. This paper presents several promising research studies investigating the application of EEG in the diagnosis of OCD; however, these studies are still in the experimental phase. In one of the proposed applications, EEG features were analyzed to evaluate their diagnostic potential for OCD and to differentiate patients with OCD from healthy individuals. The results suggest that the EEG feature based on functional connectivity, the Phase-Locking Value (PLV), shows strong potential as a biomarker for OCD. In another application, the effectiveness of transcranial direct current stimulation (tDCS) as a treatment for OCD patients was investigated through the acquisition of measurements using transcranial magnetic stimulation combined with electroencephalography (TMS-EEG). The results obtained following tDCS treatment were positive, indicating it as a potential treatment option for OCD patients; it may also be suitable for individuals with treatment-resistant OCD.| File | Dimensione | Formato | |
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https://hdl.handle.net/20.500.12608/91728