IMMUNE RESPONSE TO ALPHA-SYNUCLEIN AGGREGATION IN PARKINSON'S DISEASE

Parkinson's disease (PD) is a progressive neurodegenerative disorder involving the loss of dopaminergic neurons in the substantia nigra and the formation of intracellular α-synuclein (αSyn) aggregates known as Lewy bodies. This paper analyzes the central role of α-synuclein aggregation in PD pathophysiology and explores the immune mechanisms involved in the disease. It describes the aggregation process of the protein and its impact on chronic neuroinflammation. The main genetic and environmental risk factors are examined, focusing on the link between autoimmunity and disease onset. Finally, the paper emphasizes the processes of microglial activation and the immune response that contribute to progressive neuronal degeneration. It also highlights the importance of autoantibodies against α-synuclein as potential biomarkers for early diagnosis. Overall, the analysis emphasizes the multifactorial nature of PD and the immune system's fundamental contribution to its pathogenesis.

Parkinson's disease (PD) is a progressive neurodegenerative disorder involving the loss of dopaminergic neurons in the substantia nigra and the formation of intracellular α-synuclein (αSyn) aggregates known as Lewy bodies. This paper analyses the central role of α-synuclein aggregation in PD pathophysiology and explores the immune mechanisms involved in the disease. It describes the aggregation process of the protein and its impact on chronic neuroinflammation. The main genetic and environmental risk factors are examined, focusing on the link between autoimmunity and disease onset. Finally, the paper emphasizes the processes of microglial activation and the immune response that contribute to progressive neuronal degeneration. It also highlights the importance of autoantibodies against α-synuclein as potential biomarkers for early diagnosis. Overall, the analysis emphasizes the multifactorial nature of PD and the immune system's fundamental contribution to its pathogenesis.