The objective of this thesis is to carry out a targeted analysis and propose possible refinements to a Taylor-Couette flow reactor for large-scale pharmaceutical production under the auspices of "Brenta Pharma" in Vicenza. The project aims to improve the synthesis of specific inorganic drug carriers using a customized reactor with size and release properties that comply with specific standards to increase the efficiency of the company. This research aims to facilitate the synthesis of mesoporous silica nanoparticles using the sol-gel procedure, subsequently modified with targeted pharmacological agents and enveloped with a biocompatible polymer. The Taylor-Couette flow reactor demonstrated accurate and efficient production on a substantial scale, managing critical variables such as production rate, temperature, and residence time. The optimized system exhibited elevated drug-loading capacity, restrained drug-releasing behavior, and adjustable particle dimensions, intended to optimize therapeutic effectiveness. The analysis of data collected from trials conducted by Brenta Pharma on various samples was carried out with the aim of assessing the impact of the system on aspects such as production efficiency, cost-cutting, and yield. The results showed significant progress in production and efficacy, accompanied by substantial reductions in material wastage and manufacturing duration. In conclusion, this study facilitates the development of innovative and effective pharmaceutical production mechanisms that can be mass-produced by Brenta Pharma and similar companies, thereby improving the profitability of production and increasing the availability of medical treatments.
Questa trattazione vede come obbiettivo un’analisi mirata e possibili azioni di perfezionamento per un reattore a flusso Taylor-Couette, mirato alla produzione farmaceutica su larga scala sotto la società "Brenta Pharma" di Vicenza. Il progetto mira a migliorare la sintesi di specifici farmaci a matrice inorganica utilizzando un reattore personalizzato con caratteristiche dimensionali e di rilascio conformi a specifici standard per aumentare l'efficienza dell'azienda. Questa ricerca mira a facilitare la sintesi di nanoparticelle di silice mesoporosa attraverso la procedura sol-gel, successivamente modificate con agenti farmacologici mirati e rivestite con un polimero biocompatibile. Il reattore Taylor-Couette ha dimostrato una produzione accurata ed efficiente su scala sostanziale, gestendo variabili critiche come la velocità di produzione, la temperatura e il tempo di permanenza. Il sistema ottimizzato ha mostrato una capacità di carico del farmaco elevata, un comportamento di rilascio controllato e dimensioni delle particelle regolabili, destinate a ottimizzare l'efficacia terapeutica. L'analisi dei dati raccolti dalle prove condotte da Brenta Pharma su diversi campioni è stata effettuata al fine di valutare l'impatto del sistema su aspetti come l'efficienza di produzione, taglio dei costi e la resa. I risultati hanno mostrato notevoli progressi nella produzione e nell'efficacia, accompagnati da una sostanziale diminuzione degli sprechi di materiali e della durata di fabbricazione. In conclusione, questo studio favorisce lo sviluppo di meccanismi innovativi ed efficaci di produzione farmaceutica che possono essere prodotti in massa da Brenta Pharma e aziende analoghe, migliorando così la redditività della produzione e aumentando la disponibilità di trattamenti medici.
Analisi e sviluppo del reattore a flusso di Taylor-Couette per la sintesi di nanoparticelle di silice su larga scala
BALESTRIERI, NIKI
2022/2023
Abstract
The objective of this thesis is to carry out a targeted analysis and propose possible refinements to a Taylor-Couette flow reactor for large-scale pharmaceutical production under the auspices of "Brenta Pharma" in Vicenza. The project aims to improve the synthesis of specific inorganic drug carriers using a customized reactor with size and release properties that comply with specific standards to increase the efficiency of the company. This research aims to facilitate the synthesis of mesoporous silica nanoparticles using the sol-gel procedure, subsequently modified with targeted pharmacological agents and enveloped with a biocompatible polymer. The Taylor-Couette flow reactor demonstrated accurate and efficient production on a substantial scale, managing critical variables such as production rate, temperature, and residence time. The optimized system exhibited elevated drug-loading capacity, restrained drug-releasing behavior, and adjustable particle dimensions, intended to optimize therapeutic effectiveness. The analysis of data collected from trials conducted by Brenta Pharma on various samples was carried out with the aim of assessing the impact of the system on aspects such as production efficiency, cost-cutting, and yield. The results showed significant progress in production and efficacy, accompanied by substantial reductions in material wastage and manufacturing duration. In conclusion, this study facilitates the development of innovative and effective pharmaceutical production mechanisms that can be mass-produced by Brenta Pharma and similar companies, thereby improving the profitability of production and increasing the availability of medical treatments.File | Dimensione | Formato | |
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https://hdl.handle.net/20.500.12608/49821