The increasing interest in functional foods has driven the development of innovative strategies for probiotic delivery aimed at preserving their viability during gastrointestinal transit and enhancing their biological efficacy. In the context of modern food biotechnology, the milk fat globule membrane (MFGM) stands out as a promising natural carrier, capable of protecting beneficial microorganisms from complex gastrointestinal conditions and modulating their interactions with the intestinal mucosa. This work examines the structural, compositional, and functional characteristics of MFGM, analyzing its mechanisms of interaction with probiotics and the synergistic effects potentially associated with host health. Particular attention is given to the ability of MFGM to ensure controlled release of microorganisms, promote their adhesion, and improve their survival, highlighting advantages over conventional microencapsulation systems. A critical analysis of recent literature allows the identification of the benefits, limitations, and challenges of MFGM, providing insights for the development of safer and more effective delivery strategies. In this way, the study contributes to outlining perspectives for the industrial application of MFGM and the design of innovative functional foods based on natural vehicles for beneficial microorganisms, opening new opportunities for future research in the field.
La crescente attenzione verso gli alimenti funzionali ha stimolato l’interesse per strategie innovative di veicolazione dei probiotici, volte a preservarne la vitalità durante il transito gastrointestinale e a migliorarne l’efficacia biologica. Nel contesto delle moderne biotecnologie alimentari, la membrana dei globuli di grasso del latte (MFGM) si distingue come carrier naturale promettente, in grado di proteggere i microrganismi benefici dalle condizioni gastrointestinali complesse e di modulare le loro interazioni con la mucosa intestinale. Il lavoro approfondisce le caratteristiche strutturali, composizionali e funzionali della MFGM, analizzandone i meccanismi di interazione con i probiotici e gli effetti sinergici potenzialmente associati alla salute dell’ospite. Particolare attenzione è riservata alla capacità della MFGM di garantire un rilascio controllato dei microrganismi, di promuoverne l’adesione e di migliorarne la sopravvivenza, evidenziando vantaggi rispetto ai sistemi di microincapsulazione convenzionali. L’analisi critica della letteratura recente consente di identificare benefici, limiti e criticità della MFGM, fornendo indicazioni per lo sviluppo di strategie di delivery più sicure ed efficaci. In questo modo, il lavoro contribuisce a delineare prospettive per l’applicazione industriale della MFGM e per la progettazione di alimenti funzionali innovativi basati su veicoli naturali di microrganismi benefici, aprendo nuove possibilità per la ricerca futura nel settore.
Potenziale ruolo della membrana dei globuli di grasso del latte come carrier biologico naturale nella protezione dei probiotici durante il transito gastrointestinale
BETTIN, ASIA
2025/2026
Abstract
The increasing interest in functional foods has driven the development of innovative strategies for probiotic delivery aimed at preserving their viability during gastrointestinal transit and enhancing their biological efficacy. In the context of modern food biotechnology, the milk fat globule membrane (MFGM) stands out as a promising natural carrier, capable of protecting beneficial microorganisms from complex gastrointestinal conditions and modulating their interactions with the intestinal mucosa. This work examines the structural, compositional, and functional characteristics of MFGM, analyzing its mechanisms of interaction with probiotics and the synergistic effects potentially associated with host health. Particular attention is given to the ability of MFGM to ensure controlled release of microorganisms, promote their adhesion, and improve their survival, highlighting advantages over conventional microencapsulation systems. A critical analysis of recent literature allows the identification of the benefits, limitations, and challenges of MFGM, providing insights for the development of safer and more effective delivery strategies. In this way, the study contributes to outlining perspectives for the industrial application of MFGM and the design of innovative functional foods based on natural vehicles for beneficial microorganisms, opening new opportunities for future research in the field.| File | Dimensione | Formato | |
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https://hdl.handle.net/20.500.12608/110330